ARS-1323-alkyne
ARS-1323-alkyne is a chemical probe targeting the Switch-II pocket of KRASG12C. It serves as a conformation-specific reporter for the GTP/GDP nucleotide state in live-cell assays, facilitating research into KRAS signaling and inhibitor mechanisms in both in vitro and in vivo models.
Product Specifications
CAS Number
2436544-27-1
Product Name Alternative
ARS 1323 alkyne, ARS1323alkyne, ARS-1323-alkyne, inhibit, KRAS G12C, Inhibitor, Ras
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
98.00% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.51 mM) ; DMSO:35.71 mg/mL (62.76 mM)
Smiles
CN (CC#C) C (=O) CCNc1nc (N2CCN (CC2) C (=O) C=C) c2cc (Cl) c (c (F) c2n1) -c1c (O) cccc1F
Molecular Formula
C28H27ClF2N6O3
Molecular Weight
569
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog