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ARS-1323-alkyne

ARS-1323-alkyne is a chemical probe targeting the Switch-II pocket of KRASG12C. It serves as a conformation-specific reporter for the GTP/GDP nucleotide state in live-cell assays, facilitating research into KRAS signaling and inhibitor mechanisms in both in vitro and in vivo models.

Product Specifications

CAS Number

2436544-27-1

Product Name Alternative

ARS 1323 alkyne, ARS1323alkyne, ARS-1323-alkyne, inhibit, KRAS G12C, Inhibitor, Ras

Field of Research

Pharmacology & Drug Discovery, Signal Transduction

Purity

98.00% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.51 mM) ; DMSO:35.71 mg/mL (62.76 mM)

Smiles

CN (CC#C) C (=O) CCNc1nc (N2CCN (CC2) C (=O) C=C) c2cc (Cl) c (c (F) c2n1) -c1c (O) cccc1F

Molecular Formula

C28H27ClF2N6O3

Molecular Weight

569

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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