TLR4-IN-1

TLR4-IN-1 (compound 3k) is a potent small molecule inhibitor with an IC50 of 1.02 μM against RAW264.7 cell viability. It effectively reduces pro-inflammatory cytokine release (TNF-α, IL-1β, IL-6) in vitro and demonstrates anti-inflammatory activity in rat rheumatoid arthritis models, supporting research in immunology and inflammatory disease.