A-1155905
A-1155905 is a potent and selective MCL-1 inhibitor with an IC50 of 33.5 nM and a Ki of 0.58 nM. It disrupts the MCL-1/Bim interaction, inducing caspase-dependent apoptosis in MCL-1-dependent cancer cells in vitro, making it a valuable tool for oncology research targeting apoptotic pathways.
Product Specifications
CAS Number
2228052-37-5
Field of Research
Cell Biology, Protein Biochemistry
Smiles
O=C (O) C1=C (C=2C=CC=C (C=3C (=NN (C3COC4=CC=C (C=C4) N5CCN (C (=O) C) CC5) C) C) C2N1CCN6CCOCC6) CCCOC7=CC=CC=8C (F) =CC=CC78
Molecular Formula
C46H51FN6O6
Molecular Weight
802.93
Storage Conditions
-20°C
Notes
For research use only.
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