AJI-100
AJI-100 is a potent dual inhibitor of Aurora A kinase (IC50=12.7 nM) and JAK2 (IC50=18.5 nM) . It disrupts T cell mitosis and polarity via Aurora A and reduces STAT3 phosphorylation via JAK2, thereby suppressing TH1/TH17 differentiation. This compound is a valuable research tool for studying immune regulation and GVHD in experimental models.
Product Specifications
CAS Number
844435-10-5
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Smiles
O=C (N) C1=CC=C (C=C1) NC2=NC=C (F) C (=N2) NC=3C=CC=CC3
Molecular Formula
C17H14FN5O
Molecular Weight
323.32
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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