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HRX-0233

HRX-0233 is a MAP2K4 inhibitor that effectively shrinks H358 KRASG12C NSCLC tumors in vivo with minimal toxicity. It enhances KRAS inhibitor therapy by blocking RTK feedback, sustaining MAPK pathway suppression, and shows research potential in prostate, lung, and colon cancer models.

Product Specifications

CAS Number

2409140-12-9

Field of Research

Epigenetics & Chromatin, Signal Transduction

Purity

99.59% (May vary between batches)

Smiles

O=C (C1=CC=C (F) C (NS (=O) (=O) CCC) =C1F) C2=CNC3=NC=C (C=C32) C=4C=NC (=NC4) C5CC5

Molecular Formula

C24H21F2N5O3S

Molecular Weight

497.52

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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