PROTAC SMARCA2/4-degrader-29
PROTAC SMARCA2/4-degrader-29 (Compound I-279) is a potent, cell-permeable degrader of the SWI/SNF catalytic subunits SMARCA2 and SMARCA4, demonstrating DC50 values below 100 nM in A549 and MV411 cell lines. This tool compound is valuable for in vitro research targeting chromatin remodeling complexes in oncology and epigenetic studies.
Product Specifications
CAS Number
2568273-82-3
Field of Research
Epigenetics & Chromatin, Neuroscience, Pharmacology & Drug Discovery
Smiles
O=C1N (C=2C (=CC (=CC2) [C@@H]3CC[C@@H] (CC3) N4CCC (CC4) C=5N=C (C=CN5) N6C7CN (CC6CC7) C=8C=C (N=NC8N) C9=C (O) C=CC=C9) N1C) C%10C (=O) NC (=O) CC%10
Molecular Formula
C44H51N11O4
Molecular Weight
797.95
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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