PCSK9-IN-30

PCSK9-IN-30 (Compound 3f) is a small molecule inhibitor that binds a cryptic groove on PCSK9, blocking its interaction with the LDLR (IC50 = 537 nM) . This action restores hepatic LDL uptake, lowers plasma cholesterol in vivo, and supports research into hypercholesterolemia and cardiovascular disease mechanisms.