G-631
G-631 is a potent and selective tankyrase inhibitor with an IC50 of 7 nM against auto-PARsylation, leading to suppression of the Wnt/β-catenin pathway. It is a valuable chemical probe for studying Wnt-driven cancers and stem cell biology in both cellular and mouse models, supported by its favorable in vivo pharmacokinetics.
Product Specifications
CAS Number
1507370-78-6
Field of Research
Epigenetics & Chromatin, Molecular Biology
Smiles
O=C1N=C (NC2=C1C=NN2C) N3CCN (C4=C (F) C=C (OCCOC) C=C4F) CC3
Molecular Formula
C19H22F2N6O3
Molecular Weight
420.41
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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