NHTD
NHTD is a research compound that inhibits KRAS-PDEδ interaction by binding to the isoprenyl pocket of PDEδ, disrupting KRAS localization. This mechanism suppresses proliferation and promotes apoptosis in KRAS-mutant cells, making it a tool for studying KRAS-driven cancers like NSCLC in vitro and in vivo.
Product Specifications
CAS Number
2540915-70-4
Field of Research
Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
C (=N/NC (=O) C1=C (O) C=C (O) C=C1) \C2=C3C (OC4=C3CCCC4) =CC (C (C) (C) C) =C2O
Molecular Formula
C24H26N2O5
Molecular Weight
422.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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