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AB25583

AB25583 is a potent and selective Polθ helicase inhibitor (IC50 = 6 nM) developed for cancer research. It exhibits synthetic lethality in BRCA1/2-deficient cells and synergizes with PARP inhibitors like Olaparib, supporting its investigation in both in vitro and in vivo models of homologous recombination-deficient cancers.

Product Specifications

CAS Number

2565637-94-5

Field of Research

Cell Biology, Molecular Biology

Purity

99.21% (May vary between batches)

Smiles

O=C (NC1=NN=C (OCC2=CC=C (Cl) C=C2) S1) C=3C=NC=CC3C=4C=CC=CC4OC

Molecular Formula

C22H17ClN4O3S

Molecular Weight

452.91

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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