AB25583
AB25583 is a potent and selective Polθ helicase inhibitor (IC50 = 6 nM) developed for cancer research. It exhibits synthetic lethality in BRCA1/2-deficient cells and synergizes with PARP inhibitors like Olaparib, supporting its investigation in both in vitro and in vivo models of homologous recombination-deficient cancers.
Product Specifications
CAS Number
2565637-94-5
Field of Research
Cell Biology, Molecular Biology
Purity
99.21% (May vary between batches)
Smiles
O=C (NC1=NN=C (OCC2=CC=C (Cl) C=C2) S1) C=3C=NC=CC3C=4C=CC=CC4OC
Molecular Formula
C22H17ClN4O3S
Molecular Weight
452.91
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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