AD1058
AD1058 is a brain-penetrant, highly selective ATR inhibitor (IC50 1.6 nM) with demonstrated in vivo antitumor efficacy. It is a key research tool for studying brain/CNS metastases, where it exerts its effects by inhibiting proliferation, arresting the cell cycle, and promoting apoptosis in preclinical models.
Product Specifications
CAS Number
2907782-78-7
Product Name Alternative
AD 1058, ATM, ATR
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Molecular Biology, Signal Transduction
Purity
98.24% (May vary between batches)
Solubility
DMSO:80 mg/mL (193.95 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (12.12 mM)
Smiles
C[C@H]1N (C2=C3C (=NC (=N2) C4=C5C (=NC=C4) NC=C5) N (S (C) (=O) =O) C=C3) CCOC1
Molecular Formula
C19H20N6O3S
Molecular Weight
412.47
Storage Conditions
-20°C
Notes
For research use only.
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