WK88-1
WK88-1 is a small molecule Hsp90 inhibitor that degrades key oncogenic drivers like EGFR, ErbB2, and ErbB3. It demonstrates potent anti-proliferative and pro-apoptotic activity in resistant models such as H1975 cells, supporting its use in cancer research for investigating targeted protein degradation and overcoming therapeutic resistance.
Product Specifications
CAS Number
958888-32-9
Field of Research
Cell Biology, Metabolism Research, Signal Transduction
Smiles
CO[C@H]1CC\C=C (C) /C (=O) NC2=CC (C[C@@H] (C) C[C@H] (OC) [C@H] (O) [C@@H] (C) \C=C (C) \[C@H]1OC (N) =O) =CC=C2
Molecular Formula
C28H42N2O6
Molecular Weight
502.64
Storage Conditions
-20°C
Notes
For research use only.
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