Mcl-1 inhibitor 20

Mcl-1 inhibitor20 (compound 47) is a potent and selective small molecule antagonist of Mcl-1, binding with high affinity (Ki=24 nM) to its BH3 groove. It demonstrates favorable drug-like properties, including metabolic stability and low cardiotoxicity, supporting its use in vitro and in vivo for studying apoptosis and leukemia.