KRASG12C IN-14
KRASG12C IN-14 (compound 15) is a potent and selective inhibitor of the KRAS G12C mutant. It effectively disrupts the CYPA-dependent KRAS-BRAF interaction and suppresses ERK phosphorylation in NCI-H358 cells with an IC50 of 2 nM. This tool compound is valuable for in vitro mechanistic studies and exploring targeted oncology pathways in KRAS-driven cancers.
Product Specifications
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Molecular Formula
C51H65F4N9O9S2
Molecular Weight
1088.24
Storage Conditions
-20°C
Notes
For research use only.
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