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KRASG12C IN-14

KRASG12C IN-14 (compound 15) is a potent and selective inhibitor of the KRAS G12C mutant. It effectively disrupts the CYPA-dependent KRAS-BRAF interaction and suppresses ERK phosphorylation in NCI-H358 cells with an IC50 of 2 nM. This tool compound is valuable for in vitro mechanistic studies and exploring targeted oncology pathways in KRAS-driven cancers.

Product Specifications

Field of Research

Pharmacology & Drug Discovery, Signal Transduction

Molecular Formula

C51H65F4N9O9S2

Molecular Weight

1088.24

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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