CIB-1476

CIB-1476 is a selective caspase-1 inhibitor that blocks NLRP3 inflammasome signaling, thereby suppressing IL-1β maturation, NF-κB activation, and GSDMD-driven pyroptosis. It demonstrates potent and durable anti-inflammatory effects, effectively reducing joint swelling in murine arthritis models, making it a valuable tool for studying inflammasome-related pathways in vivo and in vitro.