MEK/RAF-IN-1

MEK/RAF-IN-1 (Compound 16b) is a potent dual MEK/RAF inhibitor with IC50 values of 28 nM for MEK1 and 3 nM for BRAF/BRAFV600E. It demonstrates robust anti-proliferative activity in KRAS-mutant cell lines and significantly inhibits tumor growth in colorectal cancer xenograft models, supporting its use in oncology research.