Nic-15
Nic-15 (compound 4n) is a small molecule that targets the low vascularity of pancreatic tumors, modulating the PI3K/Akt/mTOR pathway and alleviating ER stress to overcome gemcitabine resistance. It inhibits migration and colony formation in MIA PaCa-2 and PANC-1 cells and enhances gemcitabine efficacy in xenograft models.
Product Specifications
CAS Number
2896739-91-4
Field of Research
Signal Transduction
Smiles
C (=O) ([C@H]1[C@@H] (CC (CCC=C (C) C) =CC1) C2=C (F) C (F) =CC=C2) C3=C (O) C=CC=C3O
Molecular Formula
C25H26F2O3
Molecular Weight
412.47
Storage Conditions
-20°C
Notes
For research use only.
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