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Thalidomide-N-methylpiperazine

Thalidomide-N-methylpiperazine serves as an E3 ligase ligand-linker conjugate for constructing PROTAC MLKL Degrader-2. This molecule exhibits antinecroptotic function in human cell lines and has been shown to degrade MLKL in the HT-29 xenograft mouse model, supporting research in targeted protein degradation and necroptosis.

Product Specifications

CAS Number

2924858-30-8

Field of Research

Pharmacology & Drug Discovery

Smiles

O=C1NC (=O) C (N2C (=O) C3=CC=C (C=C3C2=O) N4CCN (C) CC4) CC1

Molecular Formula

C18H20N4O4

Molecular Weight

356.38

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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