FOXJ1 agonist 1

FOXJ1 agonist 1 (compound 16c) is an orally bioavailable small molecule that upregulates FOXJ1 to promote motile ciliogenesis in airway multiciliated cells. It demonstrates protective efficacy in elastase-induced COPD mouse models and exhibits favorable pharmacokinetic properties with low CYP/hERG inhibition and cytotoxicity, supporting its use in respiratory disease research.