SC428
SC428 is a small molecule androgen receptor (AR) inhibitor that targets the AR N-terminal domain, effectively blocking the activity of full-length AR, splice variants, and mutants. It inhibits AR nuclear translocation, chromatin binding, and downstream gene expression, demonstrating anti-proliferative effects in vitro and tumor growth suppression in 22Rv1 xenograft models through apoptosis induction.
Product Specifications
CAS Number
1898232-70-6
Field of Research
Cell Biology, Metabolism Research
Smiles
N#CC1=CC=C (C=C1C (F) (F) F) NC (=O) NC=CC=2SC=CC2
Molecular Formula
C15H10F3N3OS
Molecular Weight
337.32
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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