Trans-Ned 19

Trans-Ned 19 is a NAADP antagonist and TPC blocker. trans-Ned 19 suppresses the calcium signal and the rat aorta relaxation in response to low histamine concentrations. trans-Ned 19 increases the spontaneous acrosome reaction rate, alleviates anti-CD3 mAb-induced intestinal inflammation, and improves kidney damage in mice with nephrotoxic serum nephritis[1][2][3][4][5][6].

Product Specifications

CAS Number

[1354235-96-3]

UNSPSC

12352005

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/trans-ned-19.html

Purity

99.33

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C([C@@H]1CC2=C([C@@H](C3=CC=C(OC)C(CN4CCN(C5=CC=CC=C5F)CC4)=C3)N1)NC6=C2C=CC=C6)O

Molecular Formula

C30H31FN4O3

Molecular Weight

514.59

References & Citations

[1]Zharkich IL, et al. Suppression of Histamine-Induced Relaxation of Rat Aorta and Calcium Signaling in Endothelial Cells by Two-Pore Channel Blocker trans-NED19 and Hydrogen Peroxide. Izv Akad Nauk Ser Biol. 2016 Jul; (4) :430-438.|[2]Nawrocki M, et al. Trans-Ned 19-Mediated Antagonism of Nicotinic Acid Adenine Nucleotide-Mediated Calcium Signaling Regulates Th17 Cell Plasticity in Mice. Cells. 2021 Nov 5;10 (11) :3039.|[3]Trufanov SK, et al. The Role of Two-Pore Channels in Norepinephrine-Induced [Ca2+]i Rise in Rat Aortic Smooth Muscle Cells and Aorta Contraction. Cells. 2019 Sep 25;8 (10) :1144. |[4]Goretzko J, et al. Leukocyte adhesion is governed by endolysosomal two pore channel 2 (TPC2) . bioRxiv, 2021: 2021.09. 28.462104.|[5]Nawrocki M. Adenine dinucleotide Ca2+ mobilizing second messengers modulate CD4+ T-cells differentiation and effector function. Staats-und Universitätsbibliothek Hamburg Carl von Ossietzky, 2021.|[6]Arndt L, et al. NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa. Mol Biol Cell. 2014 Mar;25 (6) :948-64.