PROTAC SMARCA2 degrader-6
PROTAC SMARCA2 degrader-6 (I-427) is a potent and efficient small molecule that induces robust degradation of the SMARCA2 protein. It achieves a DC50 below 100 nM and over 90% degradation (Dmax) in A549 cells within 24 hours. This tool compound is valuable for probing SMARCA2 biology in cancer research and for preclinical in vitro mechanistic studies.
Product Specifications
CAS Number
2568523-72-6
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
O=C (NCC=1C=CC (=CC1) C=2SC=NC2C) C3N (C (=O) C (NC (=O) C4CC5 (C4) CC (CN6CCC (C7=CN=C (N=C7) N8C9CN (C=%10C=C (N=NC%10N) C%11=CC=CC=C%11O) CC8CC9) CC6) C5) C (C) (C) C) CC (O) C3
Molecular Formula
C56H70N12O5S
Molecular Weight
1023.30
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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