W146

W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.

Product Specifications

CAS Number

[909725-61-7]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; LPL Receptor

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/W146.html

Purity

99.83

Solubility

DMSO : 22.22 mg/mL (ultrasonic; adjust pH to 3 with TFA)

Smiles

O=C(NC1=CC=CC(CCCCCC)=C1)[C@H](N)CCP(O)(O)=O

Molecular Formula

C16H27N2O4P

Molecular Weight

342.37

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]M Germana Sanna, et al. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol. 2006 Aug;2 (8) :434-41. Epub 2006 Jul 9.|[2]Hang Wang, et al. Sphingosine-1-phosphate promotes the proliferation and attenuates apoptosis of Endothelial progenitor cells via S1PR1/S1PR3/PI3K/Akt pathway. Cell Biol Int. 2018 May 23.|[3]Jingjing Liu, et al. 3-amino-4- (3-hexylphenylamino) -4-oxobutyl phosphonic acid (W146), a Selective Antagonist of Sphingosine-1-phospahte Receptor Subtype 1, Enhances AMD3100-stimulated Mobilization of Hematopoietic Stem Progenitor Cells in Animals. J Biochem Pharmacol Res. 2013 Dec; 1 (4) : 197–203.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Cancer Commun (Lond) . 2025 Jul 16.|iScience. 2024 Oct 30;27 (12) :111290.|J Nutr Biochem. 2024 Apr:126:109587.|Nat Cell Biol. 2025 Jun;27 (6) :918-930.|Autophagy. 2025 Apr 10:1-19.