PROTAC SMARCA2 degrader-15
SMARCA2 degrader-4 (I-332) is a potent PROTAC molecule that induces robust degradation of the SMARCA2 protein. It demonstrates high potency with a DC50 below 100 nM and achieves >90% degradation in A549 cells within 24 hours, making it a valuable chemical probe for oncology and targeted protein degradation research.
Product Specifications
CAS Number
2568276-78-6
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
NC1=C (N2CC3N (C (C2) CC3) C=4N=CC (=CN4) [C@H]5CC[C@H] (CC (N[C@H] (C (=O) N6[C@H] (C (NCC7=CC=C (C=C7) C8=C (C) N=CS8) =O) C[C@@H] (O) C6) C (C) (C) C) =O) CC5) C=C (N=N1) C9=C (O) C=CC=C9
Molecular Formula
C50H61N11O5S
Molecular Weight
928.16
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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