Z32439948

Z32439948 is a butyrylcholinesterase (BChE) inhibitor (IC50: 1.4 μM, hBChE) and is a derivative of m-sulfamoylbenzamide. Z32439948 also exhibited neuroprotective effects against glutamate in SH-SY5Y cells[1].

Product Specifications

CAS Number

[920845-86-9]

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/z32439948.html

Solubility

10 mM in DMSO

Smiles

O=C(NCCC1=CNC2=C1C=CC=C2)C3=CC=C(OC)C(S(NCCC4=NC=CC=C4)(=O)=O)=C3

Molecular Formula

C25H26N4O4S

Molecular Weight

478.56

References & Citations

[1]Lu X, et al. Discovery, Structure-Based Modification, In Vitro, In Vivo, and In Silico Exploration of m-Sulfamoyl Benzoamide Derivatives as Selective Butyrylcholinesterase Inhibitors for Treating Alzheimer's Disease. ACS Chem Neurosci. 2024 Mar 20;15 (6) :1135-1156.