Z32439948
Product Specifications
UNSPSC Description
Z32439948 is a butyrylcholinesterase (BChE) inhibitor (IC50: 1.4 μM, hBChE) and is a derivative of m-sulfamoylbenzamide. Z32439948 also exhibited neuroprotective effects against glutamate in SH-SY5Y cells[1].
Target Antigen
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/z32439948.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCC1=CNC2=C1C=CC=C2)C3=CC=C(OC)C(S(NCCC4=NC=CC=C4)(=O)=O)=C3
Molecular Weight
478.56
References & Citations
[1]Lu X, et al. Discovery, Structure-Based Modification, In Vitro, In Vivo, and In Silico Exploration of m-Sulfamoyl Benzoamide Derivatives as Selective Butyrylcholinesterase Inhibitors for Treating Alzheimer's Disease. ACS Chem Neurosci. 2024 Mar 20;15(6):1135-1156.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162340/Z32439948-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162340/
Clinical Information
No Development Reported
CAS Number
920845-86-9
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