DHFR-IN-20

DHFR-IN-20 (LA1) is a potent and selective dihydrofolate reductase (DHFR) inhibitor targeting Plasmodium falciparum. It demonstrates sub-nanomolar inhibition against wild-type and quadruple-mutant PfDHFR with significant selectivity over the human enzyme. This compound is a valuable chemical tool for antimalarial drug discovery research in biochemical and cellular assays.