PROTAC SMARCA2/4-degrader-32
PROTAC SMARCA2/4-degrader-32 (I-446) is a potent, cell-permeable degrader of SMARCA2 and SMARCA4 proteins, demonstrating DC50 values below 100 nM and achieving over 90% degradation (Dmax) in A549 cells within 24 hours. This tool compound is valuable for in vitro studies exploring SWI/SNF complex function in oncology and targeted protein degradation research.
Product Specifications
CAS Number
2568273-79-8
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
NC1=C (N2CC3N (C (C2) CC3) C=4N=CC (=CN4) [C@@H]5CC[C@H] (CC5) N6CCN (CC (N[C@H] (C (=O) N7[C@H] (C (NCC8=CC=C (C=C8) C9=C (C) N=CS9) =O) C[C@@H] (O) C7) C (C) (C) C) =O) CC6) C=C (N=N1) C%10=C (O) C=CC=C%10
Molecular Formula
C54H69N13O5S
Molecular Weight
1012.28
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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