EGFR-IN-126
EGFR-IN-126 (compound 9d) is a potent small molecule inhibitor targeting the EGFR L858R/T790M/C797S triple mutant, with an IC50 of 5 nM. It demonstrates robust antitumor efficacy in both cellular assays and animal models, making it a valuable chemical probe for studying resistant non-small cell lung cancer (NSCLC) .
Product Specifications
CAS Number
2890621-88-0
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
FC=1C=CC=CC1OC2=CC=C (C=C2Br) NC=3N=CN=C4C=C (OCC5CCN (C) CC5) C (OC) =CC43
Molecular Formula
C28H28BrFN4O3
Molecular Weight
567.45
Storage Conditions
-20°C
Notes
For research use only.
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