PROTAC SMARCA2 degrader-17
PROTAC SMARCA2 degrader-17 (I-290) is a potent and efficient heterobifunctional molecule that selectively degrades the SMARCA2 protein. It demonstrates high degradation potency (DC50 < 100 nM) and achieves over 90% degradation in A549 cells within 24 hours, making it a valuable chemical probe for studying SMARCA2 function in oncology and targeted protein degradation research.
Product Specifications
CAS Number
2568276-43-5
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
O=C1NC (=O) C (N2C (=O) N (C3=CC (=CC=C32) C4CCC (N5CCC (C6=CN=C (N=C6) N7C8CN (C=9C=C (N=NC9N) C%10=CC=CC=C%10O) CC7CC8) CC5) CC4) C) CC1
Molecular Formula
C44H51N11O4
Molecular Weight
797.95
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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