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PROTAC SMARCA2 degrader-17

PROTAC SMARCA2 degrader-17 (I-290) is a potent and efficient heterobifunctional molecule that selectively degrades the SMARCA2 protein. It demonstrates high degradation potency (DC50 < 100 nM) and achieves over 90% degradation in A549 cells within 24 hours, making it a valuable chemical probe for studying SMARCA2 function in oncology and targeted protein degradation research.

Product Specifications

CAS Number

2568276-43-5

Field of Research

Neuroscience, Pharmacology & Drug Discovery

Smiles

O=C1NC (=O) C (N2C (=O) N (C3=CC (=CC=C32) C4CCC (N5CCC (C6=CN=C (N=C6) N7C8CN (C=9C=C (N=NC9N) C%10=CC=CC=C%10O) CC7CC8) CC5) CC4) C) CC1

Molecular Formula

C44H51N11O4

Molecular Weight

797.95

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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