PROTAC SMARCA2/4-degrader-7
Compound I-439 (SMARCA2/4-degrader-7) is a potent PROTAC molecule that effectively degrades SMARCA2 and SMARCA4 proteins. In A549 cells, it achieves over 90% degradation (Dmax%) with DC50 values below 100 nM within 24 hours, making it a valuable tool for probing SWI/SNF complex function in cancer research.
Product Specifications
CAS Number
2568277-89-2
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
N (C (=O) [C@H]1N (C ([C@@H] (NC (=O) [C@@H]2CC[C@H] (CC2) C=3C=NC (=NC3) N4C5CN (CC4CC5) C=6C=C (N=NC6N) C7=C (O) C=CC=C7) C (C) (C) C) =O) C[C@H] (O) C1) C8 (CC8) C9=CC=C (C=C9) C%10=C (C) N=CS%10
Molecular Formula
C51H61N11O5S
Molecular Weight
940.17
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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