PD-1/PD-L1-IN-51

PD-1/PD-L1-IN-51 (Compound III-4) is a potent small-molecule inhibitor that directly targets PD-L1 with an IC50 of 2.9 nM, effectively blocking the PD-1/PD-L1 interaction to restore T-cell function and enhance IFN-γ production. This mechanism supports its application in cancer immunotherapy research, demonstrating antitumor activity in both cellular assays and in vivo models.