PROTAC SMARCA2/4-degrader-33
PROTAC SMARCA2/4-degrader-33 (I-277) is a potent, cell-permeable small molecule that induces rapid and profound degradation of SMARCA2 and SMARCA4 proteins, achieving DC50 90% in A549 cells within 24 hours. This tool compound is valuable for probing SWI/SNF complex function in cancer biology and targeted protein degradation research, both in vitro and in vivo.
Product Specifications
CAS Number
2568276-36-6
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
NC1=C (N2CC3N (C (C2) CC3) C=4N=CC (=CN4) C5CCN (CC5) [C@H]6CC[C@H] (CC6) C=7C=C8C (=CC7) N (C (=O) N8C) C9C (=O) NC (=O) CC9) C=C (N=N1) C%10=C (O) C=CC=C%10
Molecular Formula
C44H51N11O4
Molecular Weight
797.95
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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