NA-Ir
NA-Ir is a ferroptosis inducer that targets mitochondrial DNA to activate the cGAS-STING pathway and promote ferritinophagy. Its photodynamic activity enhances ROS production, depletes GSH, and downregulates GPX4 to drive lipid peroxidation. This compound shows selective activity against cancer cells with elevated H2S levels in both cellular and animal studies.
Product Specifications
CAS Number
3031762-97-4
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research
Smiles
F[P-] (F) (F) (F) (F) F.[N-]=[N+]=NC1=CC=C2C (N (CCC (OCC3=CC (C4=CC (C) =CC=[N]4[Ir+3]567 ([C-]8=C (C9=[N]7C=CC=C9) C=CC=C8) [C-]%10=C (C%11=[N]6C=CC=C%11) C=CC=C%10) =[N]5C=C3) =O) C (C%12=CC=CC1=C%122) =O) =O
Molecular Formula
C49H36F6IrN8O4P
Molecular Weight
1138.04
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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