PROTAC SMARCA2 degrader-12
SMARCA2 degrader-13 (I-406) is a potent and selective PROTAC that induces rapid degradation of SMARCA2 protein, with a DC50 90% Dmax in A549 cells. This tool compound is valuable for in vitro studies exploring SMARCA2-dependent oncology and synthetic lethality in SMARCA4-deficient cancers.
Product Specifications
CAS Number
2568277-42-7
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
NC1=C (N2CC3N (C (C2) CC3) C=4N=CC (=CN4) C=5CC[C@H] (C (N[C@H] (C (=O) N6[C@H] (C (NCC7=CC=C (C=C7) C8=C (C) N=CS8) =O) C[C@@H] (O) C6) C (C) (C) C) =O) CC5) C=C (N=N1) C9=C (O) C=CC=C9
Molecular Formula
C49H57N11O5S
Molecular Weight
912.11
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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