JNK-1-IN-4
JNK-1-IN-4 (Compound E1) is a potent, bioavailable pan-JNK inhibitor (IC50s: 2.7-19.0 nM) that suppresses c-Jun phosphorylation and TGF-β1-induced EMT markers in vitro. It demonstrates significant antifibrotic efficacy in a bleomycin-induced mouse model of pulmonary fibrosis, supporting its use in fibrotic disease research.
Product Specifications
CAS Number
3047795-60-5
Field of Research
Signal Transduction
Smiles
O=C (N) C1=CC (OCCN (C) C) =CC=C1NC2=NC (=NC=C2Br) NC3=CC=C (OC) C=C3
Molecular Formula
C22H25BrN6O3
Molecular Weight
501.38
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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