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JNK-1-IN-4

JNK-1-IN-4 (Compound E1) is a potent, bioavailable pan-JNK inhibitor (IC50s: 2.7-19.0 nM) that suppresses c-Jun phosphorylation and TGF-β1-induced EMT markers in vitro. It demonstrates significant antifibrotic efficacy in a bleomycin-induced mouse model of pulmonary fibrosis, supporting its use in fibrotic disease research.

Product Specifications

CAS Number

3047795-60-5

Field of Research

Signal Transduction

Smiles

O=C (N) C1=CC (OCCN (C) C) =CC=C1NC2=NC (=NC=C2Br) NC3=CC=C (OC) C=C3

Molecular Formula

C22H25BrN6O3

Molecular Weight

501.38

Storage Conditions

-20°C

Notes

For research use only.

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