PROTAC SMARCA2/4-degrader-16
PROTAC SMARCA2/4-degrader-16 (I-337) is a potent, cell-permeable small molecule that induces rapid and profound degradation of SMARCA2 and SMARCA4 bromodomain proteins. It demonstrates high efficacy in cellular models (DC50 90% in A549 cells) and is a critical chemical probe for studying chromatin remodeling in cancer research, both in vitro and in vivo.
Product Specifications
CAS Number
2568273-64-1
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
NC1=C (N2CC3N (C (C2) CC3) C=4N=CC (=CN4) [C@H]5CC[C@H] (C (N[C@H] (C (=O) N6[C@H] (C (NCC7=CC=C (C=C7) C8=C (C) N=CS8) =O) C[C@@H] (O) C6) C (C) (C) C) =O) CC5) C=C (N=N1) C9=C (O) C=CC=C9
Molecular Formula
C49H59N11O5S
Molecular Weight
914.13
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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