PROTAC SMARCA2 degrader-13
SMARCA2 degrader-2 (I-322) is a potent PROTAC molecule that induces robust degradation of the SMARCA2 protein. It demonstrates a DC50 below 100 nM and achieves over 90% degradation (Dmax) within 24 hours in A549 cells, making it a valuable chemical probe for studying SWI/SNF chromatin remodeling complex biology in cancer research.
Product Specifications
CAS Number
2568276-72-0
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
O=C1NC (=O) C (N2C (=O) C=3C=CC=C (NC4CCC (N5CCC (N6N=CC (=C6) C=7C=C (N=NC7N) C=8C=CC=CC8O) CC5) CC4) C3C2=O) CC1
Molecular Formula
C37H39N9O5
Molecular Weight
689.76
Storage Conditions
-20°C
Notes
For research use only.
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