PROTAC METTL3 degrader 1
PROTAC METTL3 degrader 1 (KH12) is a potent, VHL-recruiting small molecule that induces degradation of METTL3 (DC50 = 220 nM in MOLM-13 cells) and inhibits the METTL3/14 methyltransferase complex (IC50 = 341 nM) . It demonstrates anti-proliferative activity in acute myeloid leukemia (AML) cell models, supporting its use in oncology and epitranscriptomics research.
Product Specifications
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Storage Conditions
-20°C
Notes
For research use only.
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