DA-143
DA-143 is a potent and selective DNA-PKcs inhibitor (IC50: 2.5 nM) with significantly weaker activity against mTOR, PI3KΔ, and ATM. It blocks DNA-PKcs substrate phosphorylation and, in research settings, has been shown to sensitize cancer cells to chemotherapeutic agents like doxorubicin in vitro.
Product Specifications
Field of Research
Signal Transduction
Storage Conditions
-20°C
Notes
For research use only.
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