β-catenin-IN-4
β-catenin-IN-4 (Compound 39) is a β-catenin inhibitor with a Ki of 0.64 μM. β-catenin-IN-4 reduces the protein expression levels of cyclin D1 and c-Myc[1].
Product Specifications
CAS Number
[2353536-67-9]
UNSPSC
12352005
Target
CDK; c-Myc; β-catenin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/β-catenin-in-4.html
Purity
99.84
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
O=C(N[C@H](C(NC1=CC=C(C=C1)OC(F)(F)F)=O)CCC(O)=O)[C@@H](NC([C@@H](NC(C2=CC3=C(N2)C=CC(Cl)=C3)=O)CC4=CC=C5C=CC=CC5=C4)=O)CC(O)=O
Molecular Formula
C38H33ClF3N5O9
Molecular Weight
796.14
References & Citations
[1]McCoy MA, et al. Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale. J Med Chem. 2022 May 26;65 (10) :7246-7261.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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