PROTAC SMARCA2/4-degrader-8
PROTAC SMARCA2/4-degrader-8 (I-502) is a heterobifunctional molecule that induces the degradation of SMARCA2 and SMARCA4, key catalytic subunits of the SWI/SNF chromatin remodeling complex. It demonstrates potent degradation (DC50 <100 nM) in cellular models such as A549 and MV-411 cell lines, serving as a valuable chemical probe for oncology and epigenetics research.
Product Specifications
CAS Number
2568507-14-0
Field of Research
Neuroscience
Smiles
NC1=C (N2CC3N (C (C2) CC3) C=4N=CC (=CN4) C5CCC (CC (N[C@H] (C (=O) N6[C@H] (C (NCC7=CC=C (C=C7) C8=C (C) N=CS8) =O) C[C@@H] (O) C6) C (C) (C) C) =O) CC5) C=C (N=N1) C9=C (O) C=CC=C9
Molecular Formula
C50H61N11O5S
Molecular Weight
928.16
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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