JW-65
Product Specifications
UNSPSC Description
JW-65 (compound 20) is a TRPC3 inhibitor. JW-65 can be used in neurological and cardiovascular disease related research[1].
Target Antigen
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jw-65.html
Smiles
FC(C1=C(C(NCC)=O)C=NN1C2=CC=C(C=C2)N(C=CC(Cl)=C3Cl)C3=O)(F)F
Molecular Weight
445.22
References & Citations
[1]Zhang S, et al. Discovery of a Highly Selective and Potent TRPC3 Inhibitor with High Metabolic Stability and Low Toxicity. ACS Med Chem Lett. 2021 Mar 5;12(4):572-578.|[2]Nagib MM, et al. Inhibition of TRPC3 channels by a novel pyrazole compound confers antiseizure effects. Epilepsia. 2022 Apr;63(4):1003-1015. |[3]Silva-Cardoso GK, et al. Inhibition of TRPC3 channels suppresses seizure susceptibility in the genetically-epilepsy prone rats. Eur J Pharmacol. 2024 Aug 15;977:176722.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-138668/JW-65-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-138668/
CAS Number
2763378-71-6
Available Sizes
Curated Selection
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