PROTAC SMARCA2/4-degrader-4
PROTAC SMARCA2/4-degrader-4 (I-434) is a potent, cell-permeable degrader of the SWI/SNF catalytic subunits SMARCA2 and SMARCA4. It demonstrates efficient degradation (DC50 < 100 nM) in MV411 and A549 cell lines, serving as a critical chemical probe for oncology and epigenetics research.
Product Specifications
CAS Number
2568523-81-7
Field of Research
Neuroscience
Smiles
O=C (NCC=1C=CC (=CC1) C=2SC=NC2C) C3N (C (=O) C (NC (=O) C4CC5 (C4) CC (C6=CC=C (C=C6) CN7CCC (CN8N=CC (=C8) C=9C=C (N=NC9N) C=%10C=CC=CC%10O) CC7) C5) C (C) (C) C) CC (O) C3
Molecular Formula
C56H66N10O5S
Molecular Weight
991.25
Storage Conditions
-20°C
Notes
For research use only.
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