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ABT-751 hydrochloride

ABT-751 hydrochloride is an orally bioavailable sulfonamide that binds the colchicine site on β-tubulin, inhibiting polymerization and causing G2/M arrest and apoptosis. It also induces autophagy via AKT/mTOR inhibition and has shown antitumor activity in preclinical models of lung, colon, breast, and gastric cancers.

Product Specifications

CAS Number

141450-48-8

Smiles

Cl.O=S (=O) (NC1=CC=CN=C1NC2=CC=C (O) C=C2) C3=CC=C (OC) C=C3

Molecular Formula

C18H18ClN3O4S

Molecular Weight

407.87

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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