ABT-751 hydrochloride
ABT-751 hydrochloride is an orally bioavailable sulfonamide that binds the colchicine site on β-tubulin, inhibiting polymerization and causing G2/M arrest and apoptosis. It also induces autophagy via AKT/mTOR inhibition and has shown antitumor activity in preclinical models of lung, colon, breast, and gastric cancers.
Product Specifications
CAS Number
141450-48-8
Smiles
Cl.O=S (=O) (NC1=CC=CN=C1NC2=CC=C (O) C=C2) C3=CC=C (OC) C=C3
Molecular Formula
C18H18ClN3O4S
Molecular Weight
407.87
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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