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JMV7048

JMV7048 is a potent PROTAC degrader of PXR (DC50 = 379 nM) that recruits the CRBN E3 ligase to induce PXR ubiquitination and proteasomal degradation. This activity enhances chemosensitivity in colorectal cancer stem cells and delays tumor recurrence in vivo, making it a valuable research tool for studying PXR in oncology and drug resistance.

Product Specifications

Field of Research

Pharmacology & Drug Discovery

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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